Detection of Mycobacterium tuberculosis Infection in United States Navy Recruits Using the Tuberculin Skin Test or Whole-Blood Interferon- Release Assays | Zendy

Gerald H. Mazurek | Zendy; Margan J. Zajdowicz | Zendy; Arlene Hankinson | Zendy; Dana Costigan | Zendy; Sean Toney | Zendy; J.S. Rothel | Zendy; Laura Daniels | Zendy; F. Brian Pascual | Zendy; N. Shang | Zendy; Lisa W. Keep | Zendy; Philip LoBue | Zendy

Open Access

Detection of Mycobacterium tuberculosis Infection in United States Navy Recruits Using the Tuberculin Skin Test or Whole-Blood Interferon- Release Assays

Author(s) -

Gerald H. Mazurek,

Margan J. Zajdowicz,

Arlene Hankinson,

Dana Costigan,

Sean Toney,

J.S. Rothel,

Laura Daniels,

F. Brian Pascual,

N. Shang,

Lisa W. Keep,

Philip LoBue

Publication year - 2007

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/521106

Subject(s) - medicine , tuberculin , mycobacterium tuberculosis , tuberculosis , immunology , whole blood , skin test , interferon γ , tuberculin test , virology , interferon gamma , pathology , cytokine

Military personnel are at risk for acquiring Mycobacterium tuberculosis infection because of activities in close quarters and in regions with a high prevalence of tuberculosis (TB). Accurate tests are needed to avoid unnecessary treatment because of false-positive results and to avoid TB because of false-negative results and failure to diagnose and treat M. tuberculosis infection. We sought to estimate the specificity of the tuberculin skin test (TST) and 2 whole-blood interferon-gamma release assays (QuantiFERON-TB assay [QFT] and QuantiFERON-TB Gold assay [QFT-G]) and to identify factors associated with test discordance.

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