Within‐Host Evolution for the Invasiveness of Commensal Bacteria: an Experimental Study of Bacteremias Resulting fromHaemophilus influenzaeNasal Carriage | Zendy

Elisa Margolis | Zendy; Bruce R. Levin | Zendy

Open Access

Within‐Host Evolution for the Invasiveness of Commensal Bacteria: an Experimental Study of Bacteremias Resulting fromHaemophilus influenzaeNasal Carriage

Author(s) -

Elisa Margolis,

Bruce R. Levin

Publication year - 2007

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/520934

Subject(s) - bacteria , biology , haemophilus influenzae , host (biology) , commensalism , microbiology and biotechnology , carriage , pasteurellaceae , pathogenic bacteria , disease , medicine , genetics , pathology

Many bacteria responsible for clinically relevant disease reside harmlessly in a large fraction of humans. Three explanations have been proposed to account for why these normally commensal bacteria occasionally cause invasive disease: host susceptibility, stochasticity in the host-bacteria interaction, and the evolution of invasive mutants in colonized hosts. Here we test the third of these hypotheses for the rare invasiveness of commensal bacteria: within-host evolution.

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