A Seronegative Case of HIV-1 Subtype C Infection in Botswana | Zendy

Vladimir Novitsky | Zendy; Tendani Gaolathe | Zendy; Elias Woldegabriel | Zendy; Joseph Makhema | Zendy; Max Essex | Zendy

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A Seronegative Case of HIV-1 Subtype C Infection in Botswana

Author(s) -

Vladimir Novitsky,

Tendani Gaolathe,

Elias Woldegabriel,

Joseph Makhema,

Max Essex

Publication year - 2007

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/520683

Subject(s) - medicine , genotyping , virology , human immunodeficiency virus (hiv) , antibody , western blot , viral disease , immunology , gene , genotype , biology , biochemistry

We report the first case, to our knowledge, of antibody-negative human immunodeficiency virus type 1 (HIV-1) subtype C infection, which was identified during screening for acute HIV-1 infection in Botswana. Results of tests for HIV-1 antibodies were consistently negative, including rapid and regular enzyme-linked immunosorbent assay and Western blot. The nonrecombinant HIV-1 subtype C infection was confirmed by viral genotyping within the gag, pol, and env genes. The period between referral of the patient in a clinically stable condition and AIDS-related death was approximately 3 months. The reported case indicates the importance of studying the prevalence of seronegative HIV-1 infection in southern Africa, where subtype C predominates.

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