Evaluation of Mycobacterium tuberculosis-Specific Antibody Responses in Populations with Different Levels of Exposure from Tanzania, Ethiopia, Brazil, and Denmark | Zendy

Søren T. Hoff | Zendy; Moges Tadesse Abebe | Zendy; Pernille Ravn | Zendy; Nyagosya Range | Zendy; Wabyahe L. M. Malenganisho | Zendy; D. S. Rodriques | Zendy; Esper G. Kallás | Zendy; Christian Søborg | Zendy; T. Mark Doherty | Zendy; Peter Andersen | Zendy; Karin Weldingh | Zendy

Open Access

Evaluation of Mycobacterium tuberculosis-Specific Antibody Responses in Populations with Different Levels of Exposure from Tanzania, Ethiopia, Brazil, and Denmark

Author(s) -

Søren T. Hoff,

Moges Tadesse Abebe,

Pernille Ravn,

Nyagosya Range,

Wabyahe L. M. Malenganisho,

D. S. Rodriques,

Esper G. Kallás,

Christian Søborg,

T. Mark Doherty,

Peter Andersen,

Karin Weldingh

Publication year - 2007

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/520662

Subject(s) - medicine , tanzania , tuberculosis , mycobacterium tuberculosis , latent tuberculosis , environmental health , immunology , pathology , socioeconomics , sociology

New, simple, and better-performing diagnostic tools are needed for the diagnosis of tuberculosis (TB). Much effort has been invested in developing an antibody-based test for TB, but to date, no such test has performed with sufficient sensitivity and specificity. A key question remaining is the extent to which the disappointing performance of current tests is associated with a high background prevalence of latent TB.

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