Laboratory Diagnosis of Ebola Hemorrhagic Fever during an Outbreak in Yambio, Sudan, 2004 | Zendy

Clayton Onyango | Zendy; M. Opoka | Zendy; Thomas G. Ksiazek | Zendy; Pierre Formenty | Zendy; A. A. S. Ahmed | Zendy; P.M. Tukei | Zendy; Rosemary Sang | Zendy; Victor Ofula | Zendy; Samson Kogoi | Zendy; Rodney L. Coldren | Zendy; Thomas Grein | Zendy; Dominique Legros | Zendy; M. J. Bell | Zendy; Kevin M. De Cock | Zendy; William J. Bellini | Zendy; Jonathan S. Towner | Zendy; Stuart T. Nichol | Zendy; Pierre E. Rollin | Zendy

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Laboratory Diagnosis of Ebola Hemorrhagic Fever during an Outbreak in Yambio, Sudan, 2004

Author(s) -

Clayton Onyango,

M. Opoka,

Thomas G. Ksiazek,

Pierre Formenty,

A. A. S. Ahmed,

P.M. Tukei,

Rosemary Sang,

Victor Ofula,

Samson Kogoi,

Rodney L. Coldren,

Thomas Grein,

Dominique Legros,

M. J. Bell,

Kevin M. De Cock,

William J. Bellini,

Jonathan S. Towner,

Stuart T. Nichol,

Pierre E. Rollin

Publication year - 2007

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/520609

Subject(s) - outbreak , virology , ebola virus , ebolavirus , medicine , polymerase chain reaction , measles , antibody , viral hemorrhagic fever , biology , immunology , gene , vaccination , biochemistry

Between the months of April and June 2004, an Ebola hemorrhagic fever (EHF) outbreak was reported in Yambio county, southern Sudan. Blood samples were collected from a total of 36 patients with suspected EHF and were tested by enzyme-linked immunosorbent assay (ELISA) for immunoglobulin G and M antibodies, antigen ELISA, and reverse-transcription polymerase chain reaction (PCR) of a segment of the Ebolavirus (EBOV) polymerase gene. A total of 13 patients were confirmed to be infected with EBOV. In addition, 4 fatal cases were classified as probable cases, because no samples were collected. Another 12 patients were confirmed to have acute measles infection during the same period that EBOV was circulating. Genetic analysis of PCR-positive samples indicated that the virus was similar to but distinct from Sudan EBOV Maleo 1979. In response, case management, social mobilization, and follow-up of contacts were set up as means of surveillance. The outbreak was declared to be over on 7 August 2004.

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