Assessment of a Vesicular Stomatitis Virus–Based Vaccine by Use of the Mouse Model of Ebola Virus Hemorrhagic Fever | Zendy

Steven J.M. Jones | Zendy; Ute Ströher | Zendy; Lisa Fernando | Zendy; Xianggou Qiu | Zendy; Judie B. Alimonti | Zendy; Pasquale L. Melito | Zendy; Mike Bray | Zendy; HansDieter Klenk | Zendy; Heinz Feldmann | Zendy

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Assessment of a Vesicular Stomatitis Virus–Based Vaccine by Use of the Mouse Model of Ebola Virus Hemorrhagic Fever

Author(s) -

Steven J.M. Jones,

Ute Ströher,

Lisa Fernando,

Xianggou Qiu,

Judie B. Alimonti,

Pasquale L. Melito,

Mike Bray,

HansDieter Klenk,

Heinz Feldmann

Publication year - 2007

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/520591

Subject(s) - virology , vesicular stomatitis virus , ebola vaccine , immunization , ebola virus , vaccination , vesicular stomatitis , medicine , ebolavirus , viral hemorrhagic fever , virus , immunology , vesicular stomatitis indiana virus , immune system

In humans and nonhuman primates, Ebola virus causes a virulent viral hemorrhagic fever for which no licensed vaccines or therapeutic drugs exist. In the present study, we used the mouse model for Ebola hemorrhagic fever to assess the safety and efficacy of a vaccine based on a live attenuated vesicular stomatitis virus expressing the Zaire ebolavirus (ZEBOV) glycoprotein.

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