English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

lesions in 1 week. Noncompliance with oral medications during October 1995 was associated with the appearance of new skin lesions. A new multidrug regimen was started in December 1995 with the combination of itraconazole (400 mg/d orally) and pentamidine (150 mg/d for 5 days and then 300 mg/d for 6 days intramuscularly). No improvement was observed. The initial therapeutic regimen (5fluorocytosine plus itraconazole) was administered again. Following this therapy, the course of the acanthamoeba infection altered with improvement and worsening. A granular lesion was also noted on the wall of the right nasal fossa (biopsy was refused). Parasitological examination revealed free-living amebas in purulent discharge from the left maxillary sinus in February 1996. The patient died of inanition in July 1996 after 1 year of acanthamoeba infection without clinical or radiological signs of CNS involvement; autopsy was not performed. Disseminated infections with free-living amebas in patients with HIV infection are infrequent. As of 1 October 1996, 103 cases of disseminated acanthamoeba infection had been reported worldwide [1]. Of these 103 cases, 72 were from the United States alone (including .50 cases in patients with AIDS). This infection is usually associated with a poor prognosis. Our report documents a prolonged clinical course of cutaneous and sinus infections due to Acanthamoeba in a patient with AIDS. The successive therapeutic regimens demonstrate the transient efficacy of 5-fluorocytosine. Pentamidine (in association with itraconazole) did not show efficacy against the skin lesions. Previous reports showed variability in the activity of 5-fluorocytosine, pentamidine, and itraconazole against different Acanthamoeba strains [2–6]. Furthermore, acquired resistance of Acanthamoeba to 5-fluorocytosine was suggested by different in vitro studies and other case reports [7–8]. 5-Fluorocytosine should be included in chemotherapy for disseminated infections due to free-living amebas in combination with other antiamebic agents.

Centers for Disease Control and Prevention Group O1 Bacterium–Associated Pneumonia Complicated by Bronchopulmonary Fistula and Bacteremia