Symptomatic Hyperlactatemia Associated with Nucleoside Analogue Reverse-Transcriptase Inhibitor Use in HIV-Infected Patients: A Report of 24 Cases in a Resource-Limited Setting (Uganda) | Zendy

P. M. Songa | Zendy; Barbara Castelnuovo | Zendy; E. B. Mugasha | Zendy; Ponsiano Ocama | Zendy; Andrew Kambugu | Zendy

Open Access

Symptomatic Hyperlactatemia Associated with Nucleoside Analogue Reverse-Transcriptase Inhibitor Use in HIV-Infected Patients: A Report of 24 Cases in a Resource-Limited Setting (Uganda)

Author(s) -

P. M. Songa,

Barbara Castelnuovo,

E. B. Mugasha,

Ponsiano Ocama,

Andrew Kambugu

Publication year - 2007

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/520023

Subject(s) - stavudine , medicine , hyperlactatemia , reverse transcriptase inhibitor , regimen , nucleoside reverse transcriptase inhibitor , nucleoside , human immunodeficiency virus (hiv) , nucleoside analogue , antiretroviral therapy , viral load , virology , chemistry , stereochemistry

We describe 24 Ugandan patients with human immunodeficiency virus infection who developed symptomatic hyperlactatemia associated with the use of nucleoside analogues. All patients were receiving combination therapy that contained stavudine. The median serum lactate level was 6.6 mmol/L. All patients had their antiretroviral treatment regimen discontinued. Hospital admission was required for 5 patients. Five patients died.

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