The Safety and Efficacy of Enfuvirtide Therapy for HIV Infection in Patients with Hemophilia: A Case Series | Zendy

Mark N. Polizzotto | Zendy; Alison Street | Zendy; Edwina Wright | Zendy

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The Safety and Efficacy of Enfuvirtide Therapy for HIV Infection in Patients with Hemophilia: A Case Series

Author(s) -

Mark N. Polizzotto,

Alison Street,

Edwina Wright

Publication year - 2007

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/520015

Subject(s) - enfuvirtide , medicine , salvage therapy , human immunodeficiency virus (hiv) , antiretroviral therapy , virology , sida , viral disease , immunology , chemotherapy , viral load , gp41 , epitope , antigen

The treatment of patients with human immunodeficiency virus (HIV) infection and hemophilia involves unique challenges that may be addressed with novel antiretroviral classes. We describe the safety and efficacy of enfuvirtide therapy in 4 patients with severe hemophilia A. Although local skin reactions were common, neither local nor systemic bleeding worsened. Three patients achieved undetectable HIV loads with enfuvirtide salvage regimens.

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