Levamisole Inhibits Sequestration of Infected Red Blood Cells in Patients with Falciparum Malaria | Zendy

Arjen M. Dondorp | Zendy; Kamolrat Silamut | Zendy; Prakaykaew Charunwatthana | Zendy; Sunee Chuasuwanchai | Zendy; Ronnatrai Ruangveerayut | Zendy; Somyot Krintratun | Zendy; Nicholas J. White | Zendy; May Ho | Zendy; Nicholas Day | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Levamisole Inhibits Sequestration of Infected Red Blood Cells in Patients with Falciparum Malaria

Author(s) -

Arjen M. Dondorp,

Kamolrat Silamut,

Prakaykaew Charunwatthana,

Sunee Chuasuwanchai,

Ronnatrai Ruangveerayut,

Somyot Krintratun,

Nicholas J. White,

May Ho,

Nicholas Day

Publication year - 2007

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/519287

Subject(s) - parasitemia , plasmodium falciparum , biology , malaria , quinine , immunology , levamisole , cd36 , pharmacology , receptor , biochemistry

Sequestration of infected red blood cells (iRBCs) in the microcirculation is central to the pathophysiology of falciparum malaria. It is caused by cytoadhesion of iRBCs to vascular endothelium, mediated through the binding of Plasmodium falciparum erythrocyte membrane protein-1 to several endothelial receptors. Binding to CD36, the major vascular receptor, is stabilized through dephosphorylation of CD36 by an alkaline phosphatase. This is inhibited by the alkaline phosphatase-inhibitor levamisole, resulting in decreased cytoadhesion.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research