Clinical Management of Clostridium difficile-Associated Disease | Zendy

Mark A. Miller | Zendy

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Clinical Management of Clostridium difficile-Associated Disease

Author(s) -

Mark A. Miller

Publication year - 2007

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/519257

Subject(s) - medicine , clostridium difficile , intensive care medicine , incidence (geometry) , disease , clostridium infections , colectomy , enterocolitis , clostridium , microbiology and biotechnology , antibiotics , ulcerative colitis , bacteria , physics , optics , biology , genetics

The incidence of Clostridium difficile-associated disease (CDAD) and its serious complications (including colectomy and death) have been increasing worldwide. This phenomenon is strongly associated with the appearance of a new "hypervirulent" strain in several countries. More-effective strategies are needed for the prevention and treatment of this entity. This article will review the current approaches using antimicrobials, probiotics, immunomodulation, surgery, and miscellaneous adjuvants to prevent and treat this infection.

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