Open Reading Frame 8a of the Human Severe Acute Respiratory Syndrome Coronavirus Not Only Promotes Viral Replication but Also Induces Apoptosis | Zendy

ChiaYen Chen | Zendy; YuehHsin Ping | Zendy; HsinChen Lee | Zendy; Kuan-Hsuan Chen | Zendy; Yuan-Ming Lee | Zendy; Yu-Juin Chan | Zendy; Te-Cheng Lien | Zendy; TjinShing Jap | Zendy; Chi-Hung Lin | Zendy; LungSen Kao | Zendy; YiMing Arthur Chen | Zendy

Open Access

Open Reading Frame 8a of the Human Severe Acute Respiratory Syndrome Coronavirus Not Only Promotes Viral Replication but Also Induces Apoptosis

Author(s) -

ChiaYen Chen,

YuehHsin Ping,

HsinChen Lee,

Kuan-Hsuan Chen,

Yuan-Ming Lee,

Yu-Juin Chan,

Te-Cheng Lien,

TjinShing Jap,

Chi-Hung Lin,

LungSen Kao,

YiMing Arthur Chen

Publication year - 2007

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/519166

Subject(s) - apoptosis , transfection , open reading frame , western blot , viral replication , antibody , virology , biology , mitochondrion , microbiology and biotechnology , flow cytometry , coronavirus , small interfering rna , virus , cell culture , immunology , gene , covid-19 , medicine , pathology , genetics , peptide sequence , disease , infectious disease (medical specialty)

A unique genomic difference between human and civet severe acute respiratory syndrome coronaviruses (SARS-CoVs) is that the former has a deletion of 29 nucleotides from open reading frame (orf) 8a' that results in the generation of orf8a and orf8b. The objectives of the present study were to analyze antibody reactivity to ORF8a in patients with SARS and to elucidate the function of ORF8a.

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