Human Herpesvirus 8 Seroprevalence among Prostate Cancer Case Patients and Control Subjects | Zendy

Frank J. Jenkins | Zendy; Richard B. Hayes | Zendy; Aaron Jackson | Zendy; G. Pizza | Zendy; Georgina Mbisa | Zendy; Denise Whitby | Zendy; JamesJ. Goedert | Zendy

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Human Herpesvirus 8 Seroprevalence among Prostate Cancer Case Patients and Control Subjects

Author(s) -

Frank J. Jenkins,

Richard B. Hayes,

Aaron Jackson,

G. Pizza,

Georgina Mbisa,

Denise Whitby,

JamesJ. Goedert

Publication year - 2007

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/518790

Subject(s) - seroprevalence , prostate cancer , immunofluorescence , medicine , antibody , cancer , immunology , virology , prostate specific antigen , human herpesvirus , oncology , biology , serology , virus

To investigate a possible association between human herpesvirus 8 (HHV-8) and prostate cancer, we evaluated HHV-8 seroprevalence in 2 case-control studies. HHV-8 antibodies were detected by immunofluorescence with cells expressing lytic viral proteins and by enzyme immunoassays with recombinant viral structural protein (K8.1) and latent protein (latency-associated nuclear antigen-1; open reading frame 73), respectively. HHV-8 seroprevalence tended to be lower in patients with prostate cancer than in control subjects, but there was no significant difference in either study. These data imply that HHV-8 is not a major prevalent cause of prostate cancer.

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