Dry Reagent-Based Polymerase Chain Reaction Compared with Other Laboratory Methods Available for the Diagnosis of Buruli Ulcer Disease | Zendy

Vera Siegmund | Zendy; Ohene Adjei | Zendy; Jörg Nitschke | Zendy; William A. Thompson | Zendy; Erasmus Klutse | Zendy; KarlHeinz Herbinger | Zendy; Rachel Thompson | Zendy; F. van Vloten | Zendy; Paul Rácz | Zendy; Bernhard Fleischer | Zendy; Thomas Loescher | Zendy; Gisela Bretzel | Zendy

Open Access

Dry Reagent-Based Polymerase Chain Reaction Compared with Other Laboratory Methods Available for the Diagnosis of Buruli Ulcer Disease

Author(s) -

Vera Siegmund,

Ohene Adjei,

Jörg Nitschke,

William A. Thompson,

Erasmus Klutse,

KarlHeinz Herbinger,

Rachel Thompson,

F. van Vloten,

Paul Rácz,

Bernhard Fleischer,

Thomas Loescher,

Gisela Bretzel

Publication year - 2007

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/518604

Subject(s) - buruli ulcer , medicine , polymerase chain reaction , mycobacterium ulcerans , gold standard (test) , medical diagnosis , pathology , disease , biology , biochemistry , gene

Because of the multifaceted clinical presentation of Buruli ulcer disease, misclassification of clinically diagnosed cases may occur frequently. Laboratory tests for the confirmation of suspected cases include microscopic examination, culture, polymerase chain reaction (PCR), and histopathologic examination. However, microscopic examination, the only test usually available in areas of endemicity, has a low sensitivity.

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