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Association of the Outcome of Renal Transplantation with Antibody Response to Cytomegalovirus Strain--Specific Glycoprotein H Epitopes
Author(s) -
Kenichi Ishibashi,
Tadahiko Tokumoto,
K. Tanabe,
Hiroki Shirakawa,
Koichi Hashimoto,
Nobuhiro Kushida,
Takeshi Yanagida,
Naoki Inoue,
Osamu Yamaguchi,
Hiroshi Toma,
Tatsuo Suzutani
Publication year - 2007
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1086/518571
Subject(s) - medicine , cytomegalovirus , transplantation , immunology , betaherpesvirinae , human cytomegalovirus , antibody , epitope , herpesviridae , virology , viral disease , virus
Cytomegalovirus (CMV) is the most important pathogen affecting the outcome of renal transplantation. The combination of CMV-seronegative transplant recipients with CMV-seropositive transplant donors places recipients at the highest risk of CMV disease. In cases of congenital CMV infection, existing immunity only partially protected mothers from reinfection with a different genotypic strain. The effect of differences in infected CMV strains between CMV-seropositive transplant donors and CMV seropositive transplant recipients on the outcome of transplantation remains unclear.

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