A Shared Asian Origin of the Triple‐MutantdhfrAllele inPlasmodium falciparumfrom Sites across Africa | Zendy

Oumou MaïgaAscofaré | Zendy; Abdoulaye Djimdé | Zendy; Véronique Hubert | Zendy; Emmanuelle Renard | Zendy; Agnès Aubouy | Zendy; Fred Kironde | Zendy; Basile Nsimba | Zendy; Kwadwo A. Koram | Zendy; Ogobara K. Doumbo | Zendy; Jacques Le Bras | Zendy; Jérôme Clain | Zendy

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A Shared Asian Origin of the Triple‐MutantdhfrAllele inPlasmodium falciparumfrom Sites across Africa

Author(s) -

Oumou MaïgaAscofaré,

Abdoulaye Djimdé,

Véronique Hubert,

Emmanuelle Renard,

Agnès Aubouy,

Fred Kironde,

Basile Nsimba,

Kwadwo A. Koram,

Ogobara K. Doumbo,

Jacques Le Bras,

Jérôme Clain

Publication year - 2007

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/518512

Subject(s) - plasmodium falciparum , malaria , pyrimethamine , allele , sulfadoxine/pyrimethamine , haplotype , biology , sulfadoxine , genetics , mutant , virology , immunology , gene

Usefulness of sulfadoxine-pyrimethamine as first-line therapy for uncomplicated Plasmodium falciparum malaria and intermittent preventive treatment in pregnancy throughout sub-Saharan Africa is compromised by the spread of dhfr alleles associated with pyrimethamine resistance. A predominant haplotype associated with the N51I+C59R+S108N triple-mutant dhfr allele has been reported recently in 4 African countries. A more comprehensive picture of the evolution of this mutant allele in Africa is lacking.

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