CD16+Monocyte Subset Preferentially Harbors HIV‐1 and Is Expanded in Pregnant Malawian Women withPlasmodium falciparumMalaria and HIV‐1 Infection | Zendy

Anthony Jaworowski | Zendy; Deborah Kamwendo | Zendy; Philip Ellery | Zendy; Secondo Sonza | Zendy; Victor Mwapasa | Zendy; Eyob Tadesse | Zendy; Malcolm E. Molyneux | Zendy; Stephen J. Rogerson | Zendy; Steven R. Meshnick | Zendy; Suzanne M. Crowe | Zendy

Open Access

CD16⁺Monocyte Subset Preferentially Harbors HIV‐1 and Is Expanded in Pregnant Malawian Women withPlasmodium falciparumMalaria and HIV‐1 Infection

Author(s) -

Anthony Jaworowski,

Deborah Kamwendo,

Philip Ellery,

Secondo Sonza,

Victor Mwapasa,

Eyob Tadesse,

Malcolm E. Molyneux,

Stephen J. Rogerson,

Steven R. Meshnick,

Suzanne M. Crowe

Publication year - 2007

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/518443

Subject(s) - malaria , plasmodium falciparum , monocyte , cd16 , immunology , virology , cord blood , cd14 , biology , medicine , immune system , cd8 , cd3

In a cross-sectional study, monocyte subsets in placental, cord, and maternal peripheral blood from pregnant Malawian women with human immunodeficiency virus (HIV)-1 infection and/or malaria were analyzed. HIV-uninfected Malawian women had higher baseline proportions of CD16(+) monocytes than those reported for healthy adults in developed countries. Malaria was associated with an increase in the proportion of CD16(+) monocytes that was significant in women coinfected with HIV-1. CD16(+) monocytes expressed higher CCR5 levels than did CD14(hi)/CD16(-) monocytes and were significantly more likely to harbor HIV-1. These data suggest a role for CD16(+) monocytes in the pathogenesis of maternal malaria and HIV-1 infections.

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