Cidofovir and Foscarnet for Treatment of Human Herpesvirus 6 Encephalitis in a Neutropenic Stem Cell Transplant Recipient | Zendy

Carsten Pohlmann | Zendy; Johannes Schetelig | Zendy; Ulrike Reuner | Zendy; Martin Bornhäuser | Zendy; Thomas Illmer | Zendy; Alexander Kiani | Zendy; Gerhard Ehninger | Zendy; Enno Jacobs | Zendy; Jacques Rohayem | Zendy

Open Access

Cidofovir and Foscarnet for Treatment of Human Herpesvirus 6 Encephalitis in a Neutropenic Stem Cell Transplant Recipient

Author(s) -

Carsten Pohlmann,

Johannes Schetelig,

Ulrike Reuner,

Martin Bornhäuser,

Thomas Illmer,

Alexander Kiani,

Gerhard Ehninger,

Enno Jacobs,

Jacques Rohayem

Publication year - 2007

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/518282

Subject(s) - cidofovir , foscarnet , human herpesvirus 6 , medicine , virology , encephalitis , stem cell , leukopenia , immunology , herpesviridae , viral disease , virus , chemotherapy , biology , genetics

We report a stem cell transplant recipient who developed human herpesvirus 6 encephalitis. Human herpesvirus 6 load indicated massive intrathecal viral replication. Administration of cidofovir followed by foscarnet was associated with total clearance of human herpesvirus 6 infection. Cidofovir and foscarnet combination therapy may be beneficial for reducing mortality of (neutropenic) stem cell transplant recipients with human herpesvirus 6 encephalitis.

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