Lung Fluid Immunoglobulin from HIV-Infected Subjects Has Impaired Opsonic Function against Pneumococci | Zendy

R. Eagan | Zendy; H. L. Twigg | Zendy; Neil French | Zendy; Janelisa Musaya | Zendy; Richard B. Day | Zendy; Eduard E. Zijlstra | Zendy; Helen Tolmie | Zendy; D. K. Wyler | Zendy; Malcolm E. Molyneux | Zendy; Stephen B. Gordon | Zendy

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Lung Fluid Immunoglobulin from HIV-Infected Subjects Has Impaired Opsonic Function against Pneumococci

Author(s) -

R. Eagan,

H. L. Twigg,

Neil French,

Janelisa Musaya,

Richard B. Day,

Eduard E. Zijlstra,

Helen Tolmie,

D. K. Wyler,

Malcolm E. Molyneux,

Stephen B. Gordon

Publication year - 2007

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/518133

Subject(s) - medicine , bronchoalveolar lavage , immunoglobulin g , streptococcus pneumoniae , immunology , antibody opsonization , antibody , pneumococcal pneumonia , immunoglobulin m , pneumococcal infections , opsonin , lung , microbiology and biotechnology , biology , antibiotics

The incidence of pneumococcal pneumonia is greatly increased among human immunodeficiency virus (HIV)-infected subjects, compared with among non-HIV-infected subjects. Lung fluid levels of immunoglobulin G (IgG) specific for pneumococcal capsular polysaccharide are not reduced in HIV-infected subjects; therefore, we examined immunoglobulin subtypes and compared lung fluid IgG opsonic function in HIV-infected subjects with that in healthy subjects.

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