The Importance of Leukotrienes in Mast Cell‐MediatedToxoplasma gondiiCytotoxicity | Zendy

William R. Henderson | Zendy; Y. Emil | Zendy

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The Importance of Leukotrienes in Mast Cell‐MediatedToxoplasma gondiiCytotoxicity

Author(s) -

William R. Henderson,

Y. Emil

Publication year - 1998

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/517833

Subject(s) - toxoplasma gondii , mast cell , leukotriene c4 , secretion , leukotriene , immunoglobulin e , biology , immunology , cyclooxygenase , histamine , microbiology and biotechnology , antibody , biochemistry , pharmacology , enzyme , asthma

Mast cells participate in the host defense against parasites. Mast cells release leukotrienes (LTs), potent 5-lipoxygenase (LO) products of arachidonic acid well-known to be involved in the inflammatory process. After incubation with Toxoplasma gondii, mast cells were found to degranulate and release LTB4; this interaction damages the tachyzoites. This mast cell activity against the tachyzoites was inhibited by the 5-LO inhibitor A-63162 and the 5-LO-activating protein inhibitor MK-886 but not by the cyclooxygenase inhibitor indomethacin. Reactive oxygen species were not implicated in the mast cell-mediated toxoplasmacidal activity. The generation of LTs is important for mast cell secretion, and LTB4 released by mast cells and other inflammatory cells may be a key factor in the host defense against T. gondii.

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