The Effect of Lactic Acid on Mononuclear Cell Secretion of Proinflammatory Cytokines in Response to Group B Streptococci | Zendy

Phillip M Steele | Zendy; Nancy H. Augustine | Zendy; Harry R. Hill | Zendy

Open Access

The Effect of Lactic Acid on Mononuclear Cell Secretion of Proinflammatory Cytokines in Response to Group B Streptococci

Author(s) -

Phillip M Steele,

Nancy H. Augustine,

Harry R. Hill

Publication year - 1998

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/517828

Subject(s) - proinflammatory cytokine , peripheral blood mononuclear cell , secretion , tumor necrosis factor alpha , lactic acid , septic shock , cytokine , interleukin , microbiology and biotechnology , biology , immunology , medicine , endocrinology , inflammation , chemistry , sepsis , bacteria , biochemistry , in vitro , genetics

This study found that lactate alone had a stimulatory effect (207.1 +/- 16.3%; P = .001) on tumor necrosis factor (TNF)-alpha production by human mononuclear cells with the most profound secretion being at pathologic concentrations of 4-8 mM lactate. Furthermore, exposure of these mononuclear cells to group B streptococci (GBS, 10(5) cfu) resulted in TNF-alpha production of up to 621.1 +/- 42% of control; the combination of lactic acid and GBS increased TNF-alpha production up to 1019.3 +/- 16.1% (P = .001). The combination of GBS and lactate also enhanced the secretion of interleukin (IL)-1beta and IL-6. Lactate in pathologic concentrations, therefore, likely enhances the secretion of these inflammatory mediators and contributes to septic shock and meningitis caused by GBS.

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