Clonal Spread of Group A Streptococcus with the New Type of Erythromycin Resistance | Zendy

Janne Kataja | Zendy; Pentti Huovinen | Zendy; Anna Muotiala | Zendy; Jaana VuopioVarkila | Zendy; Androulla Efstratiou | Zendy; Gillian Hallas | Zendy; the Finnish Study Group for Antimic Resistance | Zendy; Helena Seppälä | Zendy

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Clonal Spread of Group A Streptococcus with the New Type of Erythromycin Resistance

Author(s) -

Janne Kataja,

Pentti Huovinen,

Anna Muotiala,

Jaana VuopioVarkila,

Androulla Efstratiou,

Gillian Hallas,

the Finnish Study Group for Antimic Resistance,

Helena Seppälä

Publication year - 1998

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/517809

Subject(s) - erythromycin , serotype , biology , phenotype , clone (java method) , microbiology and biotechnology , streptococcus pneumoniae , streptococcaceae , streptococcus , streptococcus pyogenes , antibiotic resistance , virology , antibiotics , genetics , bacteria , staphylococcus aureus , gene

In 1990, a new type of erythromycin resistance phenotype, designated NR, was found in group A streptococcus (GAS) in Finland. In the present study, the distribution of GAS isolates with this and other erythromycin-resistance phenotypes was surveyed in Finland, and the clonality of the isolates was explored. Of 4179 GAS isolates collected from all over Finland, 695 (17%) were resistant to erythromycin, and 82% of these had the NR phenotype. Of a group of 96 isolates with the NR phenotype from different areas, 91% was T4 serotype, opacity factor-positive. The majority of these isolates were studied further: All were M4 serotype and 88% were of one clonal origin in genetic analyses. Thus, one single clone predominates among erythromycin-resistant GAS in Finland. This clone is of T4M4 serotype and mediates the new type of erythromycin resistance, characterized by the NR phenotype.

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