Accelerated Detection ofMycobacterium tuberculosisGenes Essential for Bacterial Survival in Guinea Pigs, Compared with Mice | Zendy

Sanjay K. Jain | Zendy; S. Moises HernandezAbanto | Zendy; Qijian Cheng | Zendy; Prabhpreet Singh | Zendy; Lan H. Ly | Zendy; Lee G. Klinkenberg | Zendy; Norman Morrison | Zendy; Paul J. Converse | Zendy; Eric L. Nuermberger | Zendy; J Grosset | Zendy; David N. McMurray | Zendy; Petros C. Karakousis | Zendy; Gyanu Lamichhane | Zendy; William R. Bishai | Zendy

Open Access

Accelerated Detection ofMycobacterium tuberculosisGenes Essential for Bacterial Survival in Guinea Pigs, Compared with Mice

Author(s) -

Sanjay K. Jain,

S. Moises HernandezAbanto,

Qijian Cheng,

Prabhpreet Singh,

Lan H. Ly,

Lee G. Klinkenberg,

Norman Morrison,

Paul J. Converse,

Eric L. Nuermberger,

J Grosset,

David N. McMurray,

Petros C. Karakousis,

Gyanu Lamichhane,

William R. Bishai

Publication year - 2007

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/517526

Subject(s) - mycobacterium tuberculosis , tuberculosis , microbiology and biotechnology , biology , guinea pig , gene , bacteria , virology , medicine , pathology , genetics

Mouse and guinea pig models have been used to identify Mycobacterium tuberculosis mutants attenuated for survival. However, unlike mice, M. tuberculosis-infected guinea pigs form caseating granulomas, which may simulate human disease more closely.

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