A Simple Screening Approach to Reduce B*5701-Associated Abacavir Hypersensitivity on the Basis of Sequence Variation in HIV Reverse Transcriptase | Zendy

Celia Chui | Zendy; Zabrina L. Brumme | Zendy; Chanson J. Brumme | Zendy; Benita Yip | Zendy; Elizabeth J. Phillips | Zendy; Joan Montaner | Zendy; P. Richard Harrigan | Zendy

Open Access

A Simple Screening Approach to Reduce B*5701-Associated Abacavir Hypersensitivity on the Basis of Sequence Variation in HIV Reverse Transcriptase

Author(s) -

Celia Chui,

Zabrina L. Brumme,

Chanson J. Brumme,

Benita Yip,

Elizabeth J. Phillips,

Joan Montaner,

P. Richard Harrigan

Publication year - 2007

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/517499

Subject(s) - abacavir , medicine , human leukocyte antigen , reverse transcriptase , discontinuation , hla b , virology , immunology , viral load , virus , biology , antigen , genetics , polymerase chain reaction , antiretroviral therapy , gene

Abacavir hypersensitivity is strongly associated with the human leukocyte antigen (HLA)-B*5701 allele; however, the cost of routine high-resolution HLA typing before initiation of therapy remains prohibitive. We propose a simple approach to reduce B*5701-associated abacavir hypersensitivity based on the screening of human immunodeficiency virus (HIV) reverse transcriptase (RT) for a signature B*5701-associated cytotoxic T lymphocyte escape mutation at RT codon 245.

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