A Randomized, Controlled, Molecular Study of Condylomata Acuminata Clearance during Treatment with Imiquimod | Zendy

Stephen K. Tyring | Zendy; István Arany | Zendy; Margaret Stanley | Zendy; Mark A. Tomai | Zendy; Richard L. Miller | Zendy; Michael Smith | Zendy; Daniel McDermott | Zendy; Herbert B. Slade | Zendy

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A Randomized, Controlled, Molecular Study of Condylomata Acuminata Clearance during Treatment with Imiquimod

Author(s) -

Stephen K. Tyring,

István Arany,

Margaret Stanley,

Mark A. Tomai,

Richard L. Miller,

Michael Smith,

Daniel McDermott,

Herbert B. Slade

Publication year - 1998

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/517472

Subject(s) - imiquimod , genital warts , condyloma acuminatum , tumor necrosis factor alpha , interferon , papillomaviridae , sex organ , medicine , cytokine , virus , messenger rna , immune system , hpv infection , immunology , dermatology , cancer research , biology , gene , human papillomavirus , cancer , genetics , biochemistry , cervical cancer , syphilis , human immunodeficiency virus (hiv)

Imiquimod, an immune response modifier, has been demonstrated to be safe and effective in the treatment of external genital and perianal warts caused by human papillomavirus (HPV). To identify the molecular mechanism(s) by which condylomata acuminata clear during topical treatment with imiquimod, wart skin biopsies were taken from patients before treatment, at treatment week 6, and at the end of treatment. Tissues were analyzed for HPV DNA and for mRNA of several cytokines and HPV gene products. Wart clearance was associated with evidence of tissue production of interferon-alpha, -beta, and -gamma and tumor necrosis factor-alpha. Regression of warts was strongly associated with a decrease in HPV DNA and in mRNA expression for both early and late viral proteins. Thus, topical imiquimod treatment of anogenital warts led to significant increases in local production of multiple interferon mRNAs and a significant reduction in virus load as measured by decreases in HPV DNA and mRNA for early HPV proteins.

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