Humoral Immune Responses of Africans to Cysteine Protease‐Related Antigens ofPlasmodium falciparum | Zendy

Dennis O. Gor | Zendy; Philip J. Rosenthal | Zendy

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Humoral Immune Responses of Africans to Cysteine Protease‐Related Antigens ofPlasmodium falciparum

Author(s) -

Dennis O. Gor,

Philip J. Rosenthal

Publication year - 1998

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/517455

Subject(s) - proteases , humoral immunity , plasmodium falciparum , immune system , biology , serine protease , antigen , protease , antibody , cysteine protease , immunology , virology , malaria , immunity , serine , microbiology and biotechnology , enzyme , biochemistry

The Plasmodium falciparum serine repeat antigen (SERA) and serine repeat protein homologue (SERPH) contain highly conserved domains that appear to encode cysteine proteases or related proteins. Humoral immune responses against the protease domains of SERA and SERPH were evaluated. Malaria-immune Africans, but not nonimmune controls, demonstrated potent humoral responses against the protease domains. As the SERA and SERPH protease domains are likely accessible to circulating antibody, these results suggest that humoral responses to the domains may contribute to antimalarial immunity.

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