High Levels of Human Immunodeficiency Virus Type 1 in Blood and Semen of Seropositive Men in Sub‐Saharan Africa | Zendy

John R. Dyer | Zendy; Peter N. Kazembe | Zendy; Pietro Vernazza | Zendy; Bruce L. Gilliam | Zendy; Martin Maida | Zendy; Dick Zimba | Zendy; Irving Hoffman | Zendy; Rachel A. Royce | Zendy; Jody Schock | Zendy; Susan A. Fiscus | Zendy; Myron S. Cohen | Zendy; Joseph J. Eron | Zendy

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High Levels of Human Immunodeficiency Virus Type 1 in Blood and Semen of Seropositive Men in Sub‐Saharan Africa

Author(s) -

John R. Dyer,

Peter N. Kazembe,

Pietro Vernazza,

Bruce L. Gilliam,

Martin Maida,

Dick Zimba,

Irving Hoffman,

Rachel A. Royce,

Jody Schock,

Susan A. Fiscus,

Myron S. Cohen,

Joseph J. Eron

Publication year - 1998

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/517436

Subject(s) - semen , virology , human immunodeficiency virus (hiv) , immunology , medicine , biology , andrology

High levels of human immunodeficiency virus type 1 (HIV-1) replication, as reflected in HIV-1 RNA concentrations in blood and semen, probably contribute to both rapid disease progression and enhanced sexual transmission. Semen and blood were collected from 49 Malawian and 61 US and Swiss (US/Swiss) HIV-1-seropositive men with similar CD4 cell counts and no urethritis or exposure to antiretroviral drugs. Median seminal plasma and blood plasma HIV-1 RNA concentrations were >3-fold (P = .034) and 5-fold (P = .0003) higher, respectively, in the Malawian men. Similar differences were observed in subsets of the Malawian and US/Swiss study groups matched individually for CD4 cell count (P = .035 and P < .002, respectively). These observations may help explain the high rates of HIV-1 sexual transmission and accelerated HIV-1 disease progression in sub-Saharan Africa.

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