Open AccessAnalysis of the Persistence of Humoral and Cellular Immunity in Children and Adults Immunized with Varicella Vaccine
Author(s) -
Leigh Zerboni,
Sonia Nader,
Kristan Aoki,
Ann M. Arvin
Publication year - 1998
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/517426
Subject(s) - immunology , immunity , humoral immunity , virology , persistence (discontinuity) , chickenpox vaccine , cellular immunity , varicella vaccine , medicine , vaccination , immunization , biology , immune system , geotechnical engineering , engineering
The persistence of humoral and cellular immunity to varicella-zoster virus (VZV) was evaluated in 60 children and 18 adults immunized with live attenuated VZV vaccine. At a mean of 5 years after vaccination, 93% of children and 94% of adults had IgG antibodies to VZV as determined by ELISA. VZV antibody concentrations were significantly higher at 5 years than at 1 year after immunization in children and adults. Cell-mediated immunity to VZV was detected in 87% of children and 94% of adults at 5 years. The mean stimulation index was significantly higher at 5 years than at 1 year among children and adults. Cytokine responses to VZV, including interleukin-2, interferon-gamma, and interleukin-10 were equivalent between children and adults at 5 years. In summary, varicella immunization induced long-term humoral and cellular immunity, and initial differences between cell-mediated responses in children and adults diminished over time.
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