CD8 Cell Noncytotoxic Antiviral Activity in Human Immunodeficiency Virus‐Infected and ‐Uninfected Children | Zendy

Jay A. Levy | Zendy; Frank C. Hsueh | Zendy; David J. Blackbourn | Zendy; Diane W. Wara | Zendy; Peggy Sue Weintrub | Zendy

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CD8 Cell Noncytotoxic Antiviral Activity in Human Immunodeficiency Virus‐Infected and ‐Uninfected Children

Author(s) -

Jay A. Levy,

Frank C. Hsueh,

David J. Blackbourn,

Diane W. Wara,

Peggy Sue Weintrub

Publication year - 1998

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/517378

Subject(s) - virology , cytotoxic t cell , virus , cd8 , immunology , biology , viral replication , viral disease , human immunodeficiency virus (hiv) , immune system , in vitro , genetics

CD8 cells from human immunodeficiency virus (HIV)-infected adults and children can show cytotoxic as well as noncytotoxic activity against viral replication. The noncytotoxic anti-HIV response, measured by suppression of acute viral infection of CD4 cells, has also been observed in uninfected adults who have a history of exposure to HIV. This CD8 cell antiviral activity was found to be detectable as well in approximately 50% of uninfected children born of infected mothers. The findings could reflect a protective response of the children to HIV after being exposed to the virus.

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