Prior Infection with Cytomegalovirus Is Not a Major Risk Factor for Angiographically Demonstrated Coronary Artery Atherosclerosis | Zendy

Stuart P. Adler | Zendy; Jae Kyun Hur | Zendy; Jian Ben Wang | Zendy; George W. Vetrovec | Zendy

Open Access

Prior Infection with Cytomegalovirus Is Not a Major Risk Factor for Angiographically Demonstrated Coronary Artery Atherosclerosis

Author(s) -

Stuart P. Adler,

Jae Kyun Hur,

Jian Ben Wang,

George W. Vetrovec

Publication year - 1998

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/517355

Subject(s) - medicine , coronary artery disease , risk factor , human cytomegalovirus , cytomegalovirus , cardiology , logistic regression , gastroenterology , immunology , viral disease , herpesviridae , human immunodeficiency virus (hiv) , virus

To determine if cytomegalovirus (CMV) infection is a risk factor for primary coronary artery disease (CAD), the association between CMV infection and CAD (>50% blockage in any coronary artery) was investigated in nearly 900 successive nontransplant patients undergoing coronary angiography. By use of logistic regression, older age (P <.001), white race (P <.001), gender (P <.001), hypercholesterolemia (P = .04), and other established cardiovascular risk factors (P = .003) were identified as significantly associated with CAD, but CMV seropositivity (P = .462), the level of IgG antibodies to CMV whole cell antigen (P = .98), or the levels of IgG antibodies to CMV glycoprotein B (P = .67) were not. These data suggest that CMV infection is not a major risk factor for the development of primary CAD in adults.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research