Absence of Detectable Human Herpesvirus 8 in the Semen of Human Immunodeficiency Virus‐Infected Men without Kaposi's Sarcoma | Zendy

Catherine Diamond | Zendy; MeeiLi Huang | Zendy; Dean H. Kedes | Zendy; Carl E. Speck | Zendy; George W. Rankin | Zendy; D Ganem | Zendy; Robert W. Coombs | Zendy; Timothy M. Rose | Zendy; John N. Krieger | Zendy; Lawrence Corey | Zendy

Open Access

Absence of Detectable Human Herpesvirus 8 in the Semen of Human Immunodeficiency Virus‐Infected Men without Kaposi's Sarcoma

Author(s) -

Catherine Diamond,

MeeiLi Huang,

Dean H. Kedes,

Carl E. Speck,

George W. Rankin,

D Ganem,

Robert W. Coombs,

Timothy M. Rose,

John N. Krieger,

Lawrence Corey

Publication year - 1997

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/517299

Subject(s) - semen , virology , polymerase chain reaction , peripheral blood mononuclear cell , kaposi's sarcoma , biology , virus , herpesviridae , human herpesvirus , human herpesvirus 6 , kaposi's sarcoma associated herpesvirus , viral disease , immunology , gene , biochemistry , genetics , in vitro

The prevalence of human herpesvirus 8 (HHV-8)/Kaposi's sarcoma (KS)-associated herpesvirus was investigated in the semen of 99 human immunodeficiency virus (HIV)-infected men (median CD4 cell count, 357/mm3) by use of a polymerase chain reaction (PCR) assay capable of detecting <10 copies of HHV-8 DNA. Of the subjects, 95 (96%) self-identified as men who have sex with men (MSM), and 3 had a history of clinical KS. Seminal cell specimens were negative for HHV-8 in 98 subjects. None of the 26 without KS (27.1% of 96 tested) who were seropositive for HHV-8 by IFA for latency-associated nuclear antigens had HHV-8 detected in their semen. The only subject with any evidence for seminal HHV-8 DNA was seropositive for HHV-8 and had active KS. HHV-8 was detected in 10 (10.4%) of 96 peripheral blood mononuclear cell specimens. The prevalence of HHV-8 DNA by PCR in semen of HIV-infected MSM without KS is low.

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