Papillomavirus Is Resistant to Desiccation | Zendy

Richard B.S. Roden | Zendy; Douglas R. Lowy | Zendy; John T. Schiller | Zendy

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Papillomavirus Is Resistant to Desiccation

Author(s) -

Richard B.S. Roden,

Douglas R. Lowy,

John T. Schiller

Publication year - 1997

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/516515

Subject(s) - infectivity , bovine papillomavirus , desiccation , virology , incubation , transmission (telecommunications) , biology , human papillomavirus , sex organ , genital warts , virus , in vitro , microbiology and biotechnology , medicine , human immunodeficiency virus (hiv) , botany , gene , biochemistry , syphilis , genome , electrical engineering , engineering

There is strong epidemiologic evidence for sexual transmission of high-risk genital human papillomavirus (HPV) types. However, it is unclear if infection may also be transmitted indirectly via fomites. To assess this possibility, the in vitro infectivity after desiccation was compared for pseudotype HPV-16 virions, a model for high-risk type genital HPV, and bovine papillomavirus type 1 (BPV-1), a papillomavirus known to be transmitted via fomites. The 2 viruses had similar resistance to desiccation in cell extracts, retaining approximately 100%, 50%, and 30% of infectivity when dehydrated for 1, 3, and 7 days, respectively, at room temperature. Pseudotype HPV-16 and BPV in cell extracts were completely inactivated by autoclave treatment and susceptible to 70% ethanol but were resistant to EDTA or incubation at 56 degrees C for 1 h. The data suggest that further study of nonsexual spread of high-risk genital HPV via fomites is warranted.

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