Penicillin‐ResistantStreptococcus pneumoniaein the Netherlands: Results of a 1‐Year Molecular Epidemiologic Survey | Zendy

Peter W. M. Hermans | Zendy; Marcel Sluijter | Zendy; Kees P. Elzenaar | Zendy; Ans van Veen | Zendy; Joris Schonkeren | Zendy; Floortje M. Nooren | Zendy; W J van Leeuwen | Zendy; Albert J. de Neeling | Zendy; B. van Klingeren | Zendy; Henri A. Verbrugh | Zendy; Ronald de Groot | Zendy

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Penicillin‐ResistantStreptococcus pneumoniaein the Netherlands: Results of a 1‐Year Molecular Epidemiologic Survey

Author(s) -

Peter W. M. Hermans,

Marcel Sluijter,

Kees P. Elzenaar,

Ans van Veen,

Joris Schonkeren,

Floortje M. Nooren,

W J van Leeuwen,

Albert J. de Neeling,

B. van Klingeren,

Henri A. Verbrugh,

Ronald de Groot

Publication year - 1997

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/516474

Subject(s) - penicillin , streptococcus pneumoniae , microbiology and biotechnology , genotype , pneumococcal infections , penicillin resistance , medicine , molecular epidemiology , biology , population , serotype , virology , antibiotics , gene , environmental health , genetics

The molecular epidemiologic characteristics of penicillin-resistant pneumococci in the Netherlands were investigated in 1995. Dutch electronic surveillance data showed that 0.7% of all pneumococci were intermediately resistant and 0.4% were highly resistant to penicillin. From March 1995 to March 1996, 89 penicillin-resistant isolates were collected by 39 medical microbiology laboratories. Thirty different genotypes were observed by restriction fragment end labeling. Twenty-one DNA types were unique, whereas 9 distinct genotypes were shared by > or = 2 isolates. Different serogroups were found within 6 of the 9 genetically identical clusters of penicillin-resistant isolates, suggesting that horizontal transfer of capsular genes is common. Finally, nosocomial transmission of penicillin-resistant pneumococci was observed among 21 elderly adults with chronic obstructive pulmonary disease. This study demonstrates that multiple clones of penicillin-resistant pneumococci have been introduced in the Netherlands, a country with a low prevalence of pneumococcal infection. Some clones spread among the population in and outside hospitals.

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