Life‐Threatening Parvovirus B19–Associated Myocarditis and Cardiac Transplantation as Possible Therapy: Two Case Reports | Zendy

Gisela Enders | Zendy; Jörg Dötsch | Zendy; J Bauer | Zendy; W. Nützenadel | Zendy; Hartmut Hengel | Zendy; Darrah Haffner | Zendy; Gunnar Schalasta | Zendy; Karen Searle | Zendy; Kevin Brown | Zendy

Open Access

Life‐Threatening Parvovirus B19–Associated Myocarditis and Cardiac Transplantation as Possible Therapy: Two Case Reports

Author(s) -

Gisela Enders,

Jörg Dötsch,

J Bauer,

W. Nützenadel,

Hartmut Hengel,

Darrah Haffner,

Gunnar Schalasta,

Karen Searle,

Kevin Brown

Publication year - 1998

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/516295

Subject(s) - parvovirus , myocarditis , medicine , heart transplantation , serology , transplantation , immunology , parvoviridae , virology , polymerase chain reaction , virus , antibody , gene , biology , biochemistry

Parvovirus B19 infection can cause a wide spectrum of disease syndromes. Two cases of parvovirus B19 infection were identified that resulted in life-threatening myocarditis shortly after acute infection in immunocompetent individuals. The diagnosis was made with serological and polymerase chain reaction techniques. One patient was successfully treated by heart transplantation. Sequence analysis showed that the parvovirus B19 cloned from the patients' sera had 99% homology with the prototype sequence. Clinicians should be alerted to the possible role of parvovirus B19 in myocarditis presenting in immunocompetent patients.

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