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As a part of an intervention project, all detected carriers of penicillin-resistant pneumococci (PRP) (MIC, &gt; or = 0.5 mg/L) in Malmöhus County, southern Sweden, were followed by means of weekly nasopharyngeal cultures. The median duration of carriage in 678 individuals was 19 days (range, 3-267 days). The duration of carriage was longest in children &lt; 1 year old (median, 30 days) and shortest in adults &gt; 18 years old (median, 14 days). Index cases, whose cultures were performed during an acute infection, were carriers for a mean of 10 days longer than asymptomatic contact cases (P &lt; .05). The PRP spontaneously disappeared from the nasopharynx within 4 weeks in 68%, within 8 weeks in 87%, and within 12 weeks in 94% of the individuals. Other significant risk factors for prolonged carriage were the occurrence of &gt; 6 episodes of acute otitis media (AOM) or first episode of AOM before the age of 1 year (P &lt; .01), the carriage of PRP by other family members (P &lt; .05), and the obtainment of a first positive culture during the winter months (P &lt; .05).

clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)

Duration of Nasopharyngeal Carriage of Penicillin‐Resistant<i>Streptococcus pneumoniae</i>: Experiences from the South Swedish Pneumococcal Intervention Project

Duration of Nasopharyngeal Carriage of Penicillin‐ResistantStreptococcus pneumoniae: Experiences from the South Swedish Pneumococcal Intervention Project