Acquired Drug Resistance inMycobacterium tuberculosisIsolates Recovered from Compliant Patients with Human Immunodeficiency Virus–Associated Tuberculosis | Zendy

Francesca March | Zendy; Xavier Garriga | Zendy; P. Argente Del Castillo Rodríguez | Zendy; Carmen Moreno | Zendy; Montserrat Garrigó | Zendy; Pere Coll | Zendy; Guillem Prats | Zendy

Open Access

Acquired Drug Resistance inMycobacterium tuberculosisIsolates Recovered from Compliant Patients with Human Immunodeficiency Virus–Associated Tuberculosis

Author(s) -

Francesca March,

Xavier Garriga,

P. Argente Del Castillo Rodríguez,

Carmen Moreno,

Montserrat Garrigó,

Pere Coll,

Guillem Prats

Publication year - 1997

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/516065

Subject(s) - rpob , mycobacterium tuberculosis , tuberculosis , medicine , virology , drug resistance , human immunodeficiency virus (hiv) , microbiology and biotechnology , biology , pathology

We describe five compliant patients with human immunodeficiency virus (HIV)-associated tuberculosis (TB) that relapsed, with acquisition of resistance by the original Mycobacterium tuberculosis strains. Both the first and second isolates from each patient had the same IS (insertion sequence) 6110-based DNA fingerprint patterns. Three of the five patients developed TB that was resistant to rifampin alone; no mutation in the region of the rpoB gene was detected by a line probe assay in two of the isolates from these patients. We discuss several factors presumably associated with acquired drug resistance in HIV-infected patients, including exogenous reinfection, drug interactions, malabsorption of drugs, and the presence of a large organism burden.

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