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The acute stage of feline immunodeficiency virus (FIV) infection is characterized by a CD8+ anti-FIV response that parallels the appearance of a CD8+ subpopulation with reduced expression of the beta chain (CD8 alpha + beta lo). The relationship between the CD8 alpha + beta lo phenotype and CD8+ anti-FIV activity was examined. Flow cytometric analysis of peripheral blood mononuclear cells with anti-CD8 beta chain monoclonal antibody 117 revealed that the CD8 alpha + beta lo phenotype expanded throughout the asymptomatic infection, constituting 80%-90% of the CD8 beta + cells in long-term-infected cats. Purified CD8 alpha + beta hi and CD8 alpha + beta lo subpopulations were analyzed for anti-FIV activity in an acute infection assay. Anti-FIV activity resided principally in the CD8 alpha + beta lo population and was demonstrated in acute FIV infections, as well as in long-term asymptomatic infections. These data suggest that a unique CD8 alpha + beta lo anti-FIV phenotype arises early in infection and may play a major role in eliminating virus and maintaining the asymptomatic infection.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

The CD8<sup>+</sup>Cell Phenotype Mediating Antiviral Activity in Feline Immunodeficiency Virus‐Infected Cats Is Characterized by Reduced Surface Expression of the CD8 β Chain

The CD8+Cell Phenotype Mediating Antiviral Activity in Feline Immunodeficiency Virus‐Infected Cats Is Characterized by Reduced Surface Expression of the CD8 β Chain

The CD8⁺Cell Phenotype Mediating Antiviral Activity in Feline Immunodeficiency Virus‐Infected Cats Is Characterized by Reduced Surface Expression of the CD8 β Chain