The CD8+Cell Phenotype Mediating Antiviral Activity in Feline Immunodeficiency Virus‐Infected Cats Is Characterized by Reduced Surface Expression of the CD8 β Chain | Zendy

Joseph G. Bucci | Zendy; Douglas H. Gebhard | Zendy; Tedd A. Childers | Zendy; Robert V. English | Zendy; Mary B. Tompkins | Zendy; W. A. F. Tompkins | Zendy

Open Access

The CD8⁺Cell Phenotype Mediating Antiviral Activity in Feline Immunodeficiency Virus‐Infected Cats Is Characterized by Reduced Surface Expression of the CD8 β Chain

Author(s) -

Joseph G. Bucci,

Douglas H. Gebhard,

Tedd A. Childers,

Robert V. English,

Mary B. Tompkins,

W. A. F. Tompkins

Publication year - 1998

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/515699

Subject(s) - feline immunodeficiency virus , cd8 , biology , virology , population , immunology , virus , peripheral blood mononuclear cell , cats , microbiology and biotechnology , lentivirus , immune system , medicine , viral disease , genetics , in vitro , environmental health

The acute stage of feline immunodeficiency virus (FIV) infection is characterized by a CD8+ anti-FIV response that parallels the appearance of a CD8+ subpopulation with reduced expression of the beta chain (CD8 alpha + beta lo). The relationship between the CD8 alpha + beta lo phenotype and CD8+ anti-FIV activity was examined. Flow cytometric analysis of peripheral blood mononuclear cells with anti-CD8 beta chain monoclonal antibody 117 revealed that the CD8 alpha + beta lo phenotype expanded throughout the asymptomatic infection, constituting 80%-90% of the CD8 beta + cells in long-term-infected cats. Purified CD8 alpha + beta hi and CD8 alpha + beta lo subpopulations were analyzed for anti-FIV activity in an acute infection assay. Anti-FIV activity resided principally in the CD8 alpha + beta lo population and was demonstrated in acute FIV infections, as well as in long-term asymptomatic infections. These data suggest that a unique CD8 alpha + beta lo anti-FIV phenotype arises early in infection and may play a major role in eliminating virus and maintaining the asymptomatic infection.

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