Vacuolating Toxin Production in Clinical Isolates of Helicobacter pylori with Different vacA Genotypes | Zendy

Han-Yang Wang | Zendy; ChienChih Kuo | Zendy; AnChou Yeh | Zendy; Paul C. Chang | Zendy; WenChing Wang | Zendy

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Vacuolating Toxin Production in Clinical Isolates of Helicobacter pylori with Different vacA Genotypes

Author(s) -

Han-Yang Wang,

ChienChih Kuo,

AnChou Yeh,

Paul C. Chang,

WenChing Wang

Publication year - 1998

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/515600

Subject(s) - helicobacter pylori , toxin , microbiology and biotechnology , genotype , biology , spirillaceae , helicobacter infections , gastritis , genetics , gene

A vacuolating cytotoxin encoded by vacA in Helicobacter pylori is known as a potential virulent determinant. The relationship between different vacA alleles, vacuolating ability, and H. pylori-related diseases was investigated. Genetic analysis of 119 isolates from Taiwanese patients revealed that 104 strains were s1a/m2, 13 strains were characterized as the s1a/m1T type, which was more homologous to the s1a/m1 strains, and 2 were characterized as the s1a/m1Tm2 chimeric type. Production of high-grade cytotoxin among 11 strains with s1a/m1T was higher (72.7%) than among 66 strains with s1a/m2 (21.2%) (P < .01). Peptic ulcer occurred in 76.9% of 13 patients with s1a/m1T strains compared with 46.2% of 104 patients with s1a/m2 strains (P < .05). These results suggest that s1a/m1T strains are associated with increased cytotoxic activity and higher ulcer prevalence than are s1a/m2 strains.

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