Increased Cell‐Free Viral DNA in Fatal Cases of Chronic Active Epstein‐Barr Virus Infection | Zendy

Hirokazu Kanegane | Zendy; Hiroshi Wakiguchi | Zendy; Chiharu Kanegane | Zendy; Takanobu Kurashige | Zendy; Toshio Miyawaki | Zendy; Giovanna Tosato | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Increased Cell‐Free Viral DNA in Fatal Cases of Chronic Active Epstein‐Barr Virus Infection

Author(s) -

Hirokazu Kanegane,

Hiroshi Wakiguchi,

Chiharu Kanegane,

Takanobu Kurashige,

Toshio Miyawaki,

Giovanna Tosato

Publication year - 1999

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/515224

Subject(s) - mononucleosis , medicine , virus , immunology , epstein–barr virus infection , epstein–barr virus , virology , polymerase chain reaction , herpesviridae , population , chronic infection , viral disease , immune system , biology , gene , biochemistry , environmental health

We have studied the nature of Epstein-Barr virus (EBV) infection in 33 patients with chronic active EBV infection. The study population included 14 patients with fatal chronic EBV infection and 19 patients with nonfatal chronic EBV infection, as well as 18 patients with acute EBV-induced infectious mononucleosis and 10 healthy controls. EBV DNA was measured in serum or plasma samples from the patients by semiquantitative polymerase chain reaction-based assay. EBV DNA was detected in serum or plasma samples from 62% (9/14) of patients with fatal chronic active EBV infection. In contrast, only 11% (2/19) of patients with nonfatal chronic active EBV infection and 11% (2/18) of patients with infectious mononucleosis displayed EBV DNA. None of the healthy controls tested positive. Cell-free circulating EBV DNA may represent an important feature of chronic active EBV infection and may provide a useful tool to monitor the severity of this illness.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research