A Commentary on the Pathogenesis of Pertussis | Zendy

Erik L. Hewlett | Zendy

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A Commentary on the Pathogenesis of Pertussis

Author(s) -

Erik L. Hewlett

Publication year - 1999

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/515055

Subject(s) - bordetella pertussis , virulence , pathogenesis , whooping cough , medicine , bordetella , pertussis toxin , microbiology and biotechnology , disease , infectious disease (medical specialty) , gene , immunology , virology , biology , bacteria , genetics , vaccination , g protein , pathology , receptor

In recent years a great deal of information has been generated on the virulence factors produced by Bordetella pertussis, the regulation of their expression, and their molecular mechanisms of action. There are numerous studies of Bordetella virulence factors and strains of B. pertussis in which the genes for some of these components have been mutated or deleted. In addition, several acellular vaccines composed of these virulence factors have been developed, tested, and licensed for use in the prevention of pertussis. Nevertheless, there exists little information specifically on the pathogenesis of the disease process caused by B. pertussis in humans, and such data are necessary for adequate understanding and treatment of this novel infectious disease.

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