Fatal Pancarditis Associated with Human Granulocytic Ehrlichiosis in a 44‐Year‐Old Man | Zendy

Arshad Jahangir | Zendy; C. P. Kolbert | Zendy; William Edwards | Zendy; Paul D. Mitchell | Zendy; J. Stephen Dumler | Zendy; David H. Persing | Zendy

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Fatal Pancarditis Associated with Human Granulocytic Ehrlichiosis in a 44‐Year‐Old Man

Author(s) -

Arshad Jahangir,

C. P. Kolbert,

William Edwards,

Paul D. Mitchell,

J. Stephen Dumler,

David H. Persing

Publication year - 1998

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/515014

Subject(s) - ehrlichiosis , lyme disease , ehrlichia , medicine , borrelia burgdorferi , serology , tick , tick borne disease , ehrlichia chaffeensis , virology , ixodes , immunology , antibody

Human cases of infection with a granulocytotropic Ehrlichia species closely related to Ehrlichia equi are now being described with increasing frequency in the United States, especially in areas where Lyme disease is already endemic. We describe a case of fatal pancarditis during the course of human granulocytic ehrlichiosis (HGE) in a 44-year-old outdoor worker who was previously treated for presumptive Lyme disease. Serological and molecular diagnostic tests for Borrelia burgdorferi and Babesia microti infections were negative. Postmortem serum specimens were seroreactive for HGE, and molecular evidence of infection with the HGE agent was obtained. These findings suggest that carditis may be a manifestation of HGE, further complicating the differential diagnosis of tick-borne illness.

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