Prevalence of Antibody toTrypanosoma cruziin Pregnant Hispanic Women in Houston | Zendy

M. Cecilia Di Pentima | Zendy; LuYu Hwang | Zendy; Claire M. Skeeter | Zendy; Morven S. Edwards | Zendy

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Prevalence of Antibody toTrypanosoma cruziin Pregnant Hispanic Women in Houston

Author(s) -

M. Cecilia Di Pentima,

LuYu Hwang,

Claire M. Skeeter,

Morven S. Edwards

Publication year - 1999

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/514790

Subject(s) - seroprevalence , trypanosoma cruzi , medicine , chagas disease , antibody , immunology , pregnancy , hemagglutination assay , hemagglutination , virology , serology , biology , parasite hosting , titer , world wide web , computer science , genetics

We assessed the seroprevalence of antibodies to Trypanosoma cruzi among pregnant Hispanic women in Houston. Sera from 2,107 Hispanic and 1,658 non-Hispanic subjects were tested by ELISA for the presence of antibodies to T. cruzi. Twenty-two (0.6%) of 3,765 subjects had sera that were reactive. Seroreactivity was confirmed by hemagglutination assay. Eleven subjects had reactive sera, giving a confirmed seroprevalence of 0.3% (95% CI, 0-1%). Nine sera from Hispanic and two from non-Hispanic women were positive by hemagglutination assay, for a prevalence of 0.4% and 0.1%, respectively, during pregnancy. On the basis of these seroreactivity data, transplacental transmission of T. cruzi could occur in the continental United States. Screening for antibodies to T. cruzi during pregnancy would provide the potential for early intervention in congenital Chagas' disease.

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