Association between High Levels of Blood Macrophage Migration Inhibitory Factor, Inappropriate Adrenal Response, and Early Death in Patients with Severe Sepsis | Zendy

Marieke Emonts | Zendy; Fred C.G.J. Sweep | Zendy; Nicolaï Grebenchtchikov | Zendy; Anneke GeurtsMoespot | Zendy; M. Knaup | Zendy; A. Chanson | Zendy; Véronique Erard | Zendy; Pascal Renner | Zendy; Peter W. M. Hermans | Zendy; Jan A. Hazelzet | Zendy; Thierry Calandra | Zendy

Open Access

Association between High Levels of Blood Macrophage Migration Inhibitory Factor, Inappropriate Adrenal Response, and Early Death in Patients with Severe Sepsis

Author(s) -

Marieke Emonts,

Fred C.G.J. Sweep,

Nicolaï Grebenchtchikov,

Anneke GeurtsMoespot,

M. Knaup,

A. Chanson,

Véronique Erard,

Pascal Renner,

Peter W. M. Hermans,

Jan A. Hazelzet,

Thierry Calandra

Publication year - 2007

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/514344

Subject(s) - macrophage migration inhibitory factor , sepsis , medicine , septic shock , adrenocorticotropic hormone , immunology , hormone , cytokine

Identification of new therapeutic targets remains an imperative goal to improve the morbidity and mortality associated with severe sepsis and septic shock. Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine and counterregulator of glucocorticoids, has recently emerged as a critical mediator of innate immunity and experimental sepsis, and it is an attractive new target for the treatment of sepsis.

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