Single Amino Acid Change in DNA Polymerase Is Associated with Foscarnet Resistance in a Varicella‐Zoster Virus Strain Recovered from a Patient with AIDS | Zendy

Bertrand Visse | Zendy; Bruno Dumont | Zendy; JeanMarie Huraux | Zendy; AnneMarie Fillet | Zendy

Open Access

Single Amino Acid Change in DNA Polymerase Is Associated with Foscarnet Resistance in a Varicella‐Zoster Virus Strain Recovered from a Patient with AIDS

Author(s) -

Bertrand Visse,

Bruno Dumont,

JeanMarie Huraux,

AnneMarie Fillet

Publication year - 1998

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/514257

Subject(s) - foscarnet , virology , point mutation , mutation , virus , strain (injury) , biology , varicella zoster virus , polymerase chain reaction , viral disease , herpesviridae , genetics , gene , anatomy

The genetic characterization of a foscarnet-resistant strain of varicella-zoster virus (VZV) that was isolated from a patient with AIDS is reported. Compared with the sequence of the Dumas reference strain, this strain, which was isolated from a patient in whom foscarnet treatment failed, had two point mutations. The emergence of one of the mutations, which includes a change from a glutamic acid to a lysine at position 512 in the DNA polymerase, suggests that this mutation is implicated in the VZV foscarnet resistance. The other mutation, which replaces serine 863 by a glycine, is also present in 2 susceptible strains--Oka and a wild-type isolate.

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