Open AccessDual Skin Testing withMycobacterium aviumSensitin and Purified Protein Derivative to Discriminate Pulmonary Disease Due toM. aviumComplex from Pulmonary Disease Due toMycobacterium tuberculosis
Author(s) -
C. Fordham von Reyn,
David E. Williams,
C. Robert Horsburgh,
Anna S. Jaeger,
Bryan J. Marsh,
K Hasløv,
Mogens Magnusson
Publication year - 1998
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/514225
Subject(s) - pulmonary disease , mycobacterium tuberculosis , mycobacterium , mycobacterium avium complex , pulmonary tuberculosis , microbiology and biotechnology , tuberculosis , disease , purified protein derivative , medicine , nontuberculous mycobacteria , virology , biology , pathology
Skin testing with Mycobacterium avium sensitin (MAS) RS 10/2 and purified protein derivative (PPD) was conducted on patients with pulmonary disease due to M. avium complex (MAC) or Mycobacterium tuberculosis (MTB) and no known immunodeficiency. Reactions > or = 5 mm to either MAS or PPD were present in 37 (84%) of 44 MAC patients and 28 (97%) of 29 MTB patients. MAC patients had a mean MAS reaction of 13.8 (+/-8.3) mm and a mean PPD reaction of 3.5 (+/-8.6) mm (P < .001). MTB patients had a mean MAS reaction of 17.9 (+/-9.4) mm and a mean PPD reaction of 22.9 (+/-11.4) mm (P < .001). MAS-dominant skin tests (MAS reaction > or = 5 mm larger than PPD reaction) were present in 32 (73%) of 44 MAC patients and 1 (3%) of 29 MTB patients. MAS-dominant skin tests had a specificity of 97% for discriminating MAC disease from MTB disease.
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