Simian Immunodeficiency Virus Burden in Tissues and Cellular Compartments during Clinical Latency and AIDS | Zendy

Todd A. Reinhart | Zendy; Michael Rogan | Zendy; David A. Huddleston | Zendy; Dianne M. Rausch | Zendy; Lee E. Eiden | Zendy; Ashley T. Haase | Zendy

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Simian Immunodeficiency Virus Burden in Tissues and Cellular Compartments during Clinical Latency and AIDS

Author(s) -

Todd A. Reinhart,

Michael Rogan,

David A. Huddleston,

Dianne M. Rausch,

Lee E. Eiden,

Ashley T. Haase

Publication year - 1997

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/514113

Subject(s) - simian immunodeficiency virus , virus , virology , biology , viral disease , lentivirus , immunology , pathogenesis , immunopathology , simian , oncovirus , virus latency , lymphatic system , viral replication

In the course of human immunodeficiency virus infection or of the related simian immunodeficiency virus (SIV), progression to AIDS is associated with high virus burdens in blood. How virus burden in the bloodstream is related to virus burden in tissue reservoirs was addressed in an animal model of rhesus macaques infected with SIV. In situ hybridization and quantitative image analysis were used to quantitate virus burden. Animals who developed AIDS had high levels of virus production and storage in lymphoid tissue reservoirs and evidence of productive infection of macrophages in the nervous system. With the quantitative approach described, it should be possible to design and assess the impact of treatment and shed light on the outstanding issues in pathogenesis.

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