Widespread Dissemination of a Drug‐Susceptible Strain ofMycobacterium tuberculosis | Zendy

Cindy R. Friedman | Zendy; Geoff C. Quinn | Zendy; Barry N. Kreiswirth | Zendy; David C. Perlman | Zendy; Nadim Salomon | Zendy; Neil W. Schluger | Zendy; Michael Lutfey | Zendy; Judith Berger | Zendy; Natasha Poltoratskaia | Zendy; Lee W. Riley | Zendy

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Widespread Dissemination of a Drug‐Susceptible Strain ofMycobacterium tuberculosis

Author(s) -

Cindy R. Friedman,

Geoff C. Quinn,

Barry N. Kreiswirth,

David C. Perlman,

Nadim Salomon,

Neil W. Schluger,

Michael Lutfey,

Judith Berger,

Natasha Poltoratskaia,

Lee W. Riley

Publication year - 1997

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/514067

Subject(s) - mycobacterium tuberculosis , strain (injury) , tuberculosis , microbiology and biotechnology , tubercle , drug resistance , cluster (spacecraft) , biology , bacillus (shape) , virology , bacteria , medicine , bacilli , pathology , genetics , computer science , anatomy , programming language

In New York City, a large proportion of new tuberculosis cases has been caused by 1 drug-susceptible strain (called C strain) of Mycobacterium tuberculosis. Between 1991 and 1994, among >600 tuberculosis patients consecutively identified in four large hospitals in the city, 54 with C strain, 69 with non-C cluster pattern strains, and 42 with noncluster pattern strains were studied. Susceptibility to reactive nitrogen intermediates (RNI) of selected isolates was compared. In a case-control analysis, 51% of patients with C strain, 28% with non-C cluster strains (P < .05), and 14% with noncluster strains (P < .01) were found to be injection drug users. C strain but not 13 other unrelated isolates were resistant to RNI. Injection drug use may provide a selective pressure for an RNI-resistant tubercle bacillus to emerge, which may give the organism a biologic advantage and explain the widespread dissemination of C strain M. tuberculosis within the city.

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