Detection of Infection with Human Immunodeficiency Virus Type 1 before Seroconversion: Correlation with Clinical Symptoms and Outcome | Zendy

John Phair | Zendy; Joseph B. Margolick | Zendy; Lisa P. Jacobson | Zendy; Jack F. Phillips | Zendy; Charles R. Rinaldo | Zendy; Richard A. Kaslow | Zendy; Clara Chu | Zendy; Janis V. Giorgi | Zendy; Denis Henrard | Zendy

Open Access

Detection of Infection with Human Immunodeficiency Virus Type 1 before Seroconversion: Correlation with Clinical Symptoms and Outcome

Author(s) -

John Phair,

Joseph B. Margolick,

Lisa P. Jacobson,

Jack F. Phillips,

Charles R. Rinaldo,

Richard A. Kaslow,

Clara Chu,

Janis V. Giorgi,

Denis Henrard

Publication year - 1997

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/514000

Subject(s) - seroconversion , multicenter aids cohort study , asymptomatic , medicine , immunology , viral disease , antibody , cohort , virus , sida , human immunodeficiency virus (hiv) , immunopathology , virology

Early (pre-seroconversion) infection with human immunodeficiency virus type 1 (HIV-1) was identified in 50 of 267 participants in the Multicenter AIDS Cohort Study. These 50 men had a positive EIA result, which detected IgM antibody (n = 35), p24 antigen, or serum HIV RNA (n = 15) at their last "seronegative" visit. At that visit, the mean CD4 lymphocyte number (890/mm3 vs. 1038/mm3) was significantly lower than in men who subsequently seroconverted but had no evidence of early infection. The decline in CD4 cells was slower and the duration of AIDS-free time longer in the 19 men who were symptomatic in comparison to the 31 asymptomatic men with early infection, but differences were not significant.

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