Mucosally Transmitted Feline Immunodeficiency Virus Induces a CD8+Antiviral Response that Correlates with Reduction of Cell‐Associated Virus | Zendy

Joseph G. Bucci | Zendy; Robert V. English | Zendy; Holly L. Jordan | Zendy; Tedd A. Childers | Zendy; Mary B. Tompkins | Zendy; W. A. F. Tompkins | Zendy

Open Access

Mucosally Transmitted Feline Immunodeficiency Virus Induces a CD8⁺Antiviral Response that Correlates with Reduction of Cell‐Associated Virus

Author(s) -

Joseph G. Bucci,

Robert V. English,

Holly L. Jordan,

Tedd A. Childers,

Mary B. Tompkins,

W. A. F. Tompkins

Publication year - 1998

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/513822

Subject(s) - feline immunodeficiency virus , virology , virus , cd8 , viral replication , peripheral blood mononuclear cell , biology , immune system , immunology , immunity , cats , cytotoxic t cell , lentivirus , viral disease , medicine , in vitro , biochemistry

Intravaginal inoculation of cats with feline immunodeficiency virus (FIV) results in acute systemic infection accompanied by a strong CD8+ immune response that inhibits viral replication. CD8+ anti-FIV activity, revealed by increased FIV replication in peripheral blood mononuclear cells (PBMC) depleted of CD8+ lymphocytes, was detected by 6 weeks after inoculation and correlated with reduced PBMC-associated virus at 12, 16, and 32 weeks after inoculation. Some cats with strong CD8+ anti-FIV activity during acute infection did not seroconvert and yielded no evidence of FIV infection at later times. These data suggest that CD8+ immunity may play a major role in eliminating virus during primary transmucosal FIV infection and may down-regulate viral replication during asymptomatic infection.

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