Open AccessIndividuals with Pulmonary Tuberculosis Have Lower Levels of Circulating CD1d‐Restricted NKT Cells
Author(s) -
Jennifer SnyderCappione,
Douglas F. Nixon,
Christopher P. Loo,
Joan M. Chapman,
Duncan A. Meiklejohn,
Fernando Fiúza de Melo,
Priscilla R. Costa,
Johan K. Sandberg,
Denise S. Rodrigues,
Esper G. Kallás
Publication year - 2007
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/513567
Subject(s) - natural killer t cell , immunology , cd1d , tuberculosis , mycobacterium tuberculosis , peripheral blood mononuclear cell , immunity , medicine , cellular immunity , biology , antigen , immune system , t cell , pathology , in vitro , biochemistry
Mycobacterium tuberculosis (MTB) is a leading cause of mortality worldwide from an infectious agent. Natural killer T (NKT) cells recognize mycobacterial antigens and contribute to anti-MTB immunity in mouse models. NKT cells were measured in subjects with pulmonary tuberculosis, MTB-exposed individuals, and healthy controls. NKT cell levels are selectively lower in peripheral blood mononuclear cells from individuals with pulmonary tuberculosis than in both MTB-exposed subjects and healthy control subjects. This apparent loss of NKT cells from the peripheral blood is sustained during the 6 months after the initiation of MTB treatment. These findings indicate that NKT cells may be an important component of antituberculosis immunity.
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